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I too suggest asking her PCP for a narcotic pain medication or even a low dose fentanyl patch. As CM stated, you have to “stay ahead” of the pain and routinely administer the pain med to maintain a level.
Often Tylenol is just not effective.
You already know not to give NSAIDS or aspirin due to additional blood thinning side effects.
Can the PT perhaps suggest stretching and moving exercises that your grandmother can do that are more comfortable for her? If you can get her to move a little bit in a way that is enjoyable, or at least not unpleasant, perhaps it will boost her morale and spur her on.
You can also ask about warming pads and gels to relieve her back pain, but don't do this without medical approval and watch out for skin issues.
How would your grandmother feel about massage? You might find an aromatherapist with a special interest in older clients.
NSAIDs are blood-thinners, is the trouble there. I suppose in a way we're victims of the sophistication of our pharmaceutical arsenal nowadays. They've cleverly developed improved anticoagulants without the drawbacks of NSAIDs; the difficulty is that they don't either have all the same therapeutic effects. I think it was Walt Whitman who said: "what we call progress is merely the exchange of one nuisance for another nuisance."