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Maybe your niece is so involved that you could discuss this with her and if she can't competently answer something then maybe that would open the door for you to be able to talk to the doctor.
One thing that I see repeatedly on this site is upset POAs that are the boots on the ground help being frustrated by long distance family criticizing them but never helping them. They shut down and stop communicating because they have enough on their plate dealing with their loved one. Something to consider when talking with your niece. Honestly, as a POA she doesn't need to see him frequently or do any hands on, yet she is doing this, sacrificing other areas of her life to do so.
As far as the relationship with POA, perhaps that can be healed. Expressing why you want to be aware of your fathers health details might help. If it becomes a power struggle that can be rough.
best wishes
Your father's doctor may not share info with you, but if you're just worried about this particular medication, then there is nothing to preclude you from informing your father's doctor of your concerns. This may not change the current plan, but at least your father's doctor might think more carefully about prescribed medications if he/she knows a caring family member is concerned.
One of my best friends, in her 60s, has unremitting depression She is on Seroquel. It works. It allows her to work and remain sane. Geriatric psychiatric is an art.