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If the mess is spilling out into their yard and they are in a residential neighborhood I'm sure someone has already tried reporting them to the city. As long as his wife is (maybe) being a buffer, nothing will happen until one of them has a crisis.
A doctor can't do anything except treat the person in front of them for the symptoms they are complaining about. Again, the wife is holding down a job and is seemingly functional outside the home, able to do ADLs.
The animals can be checked for neglect, that's about it. If the animal welfare or ASPCA is allowed into the basement to check the rabbits, not sure if they can report what they find elsewhere in the house.
I would call Animal welfare. They will need to get to the basement for the rabbits and will see the house and hopefully call APS or the HealthDept.
It should be reported to the County through Sheriff or Police as to safety conditions on the property. They are the ones who can do followup with asking that the situation be "cleaned up" or the property condemned. That said, where would that leave the brother and his wife?
His skin condition could be anything. Either related to the house or not. Often there is no running water or bathing facilities, or even flushing toilets in these homes.
This is a national problem at this time.
It's truly sad but I think that family AND governmental authorities feel helpless to find a way to address it. It is now a part of the DSM-5: this from the internet:
"Hoarding Disorder DSM-5 300.3 (F42) - Therapedia
WebDSM-5 reports that 2% to 6% of the population have a hoarding disorder. Although hoarding is more common in older adults (55-94 years), it appears to begin at 11-15 years, and starts to cause significant impairment when people are in their 30’s (DSM-5).
EXPLORE FURTHER
How To Help A Hoarder: 5 Things You Should Never Say To A …
unclutteredsimplicity.com
Hoarding disorder: a new diagnosis for DSM-V? - PubMed
pubmed.ncbi.nlm.nih.gov
Hoarding Disorder | New England Journal of Medicine
nejm.org
Hoarding disorder - Diagnosis and treatment - Mayo Clinic
mayoclinic.org
The 5 Stages of Hoarding Disorder | Hoarders 911
hoarders911.com
10 Signs of Hoarding Disorder and 3 Psychological Causes …
lifeadvancer.com"
So
There's a ton of stuff out there on the internet. But what to do if you are the sister?
I honestly haven't a clue.
I personally would start with APS if I were going to intervene.
Intervention may spell the loss of everything for this couple. I would be hesitant to be responsible for that.
Maybe just be a good listener for your friend; I just don't know.
But I will tell her both of those things.
She brings him up to me often , so I know it really upsets her, and I don't believe she is exaggerating. So I figured I'd ask. Thanks