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He went to the hospital for what turned out to be the last time--after he passed I was cleaning and pulled out his recliner. Underneath were hundreds of pills. He hadn't taken anything for well over a month. I just chuckled under my breath and said "You won, dad".
Now, I will state that nothing he was taking was "life altering"..and the side effects...mostly gastro problems--just not worth it.
I agree with Black hole. This could well be your dad's way of saying "I'm DONE!"
I plan to quit all meds when I am 70. I have no desire to live forever, and I see my mother shoveling down 20+ pills a day and I wonder, "why????"
Once pills are minimized, then it's time to make boundaries. If Dad is unmanageable at home when he won't take his pills, you can make a rule that he has to go to memory care or asst living after x number of days straight, or x times. This is a sign of mental decline and it won't get better. Instead of driving yourself crazy trying to manage, set this number so you have a line in the sand as to when it is time for placement.
Or perhaps you can offer something pleasurable after he takes him, such as a little bit of ice cream, his favorite music (just put it on and play it, but only after taking meds)....little things that he associates with taking meds on a subconscious level.
Since Dad was in a senior facility, I was able to use a paid option of having a "med-tech" who worked at the facility come in twice a day to give Dad his meds. His meds were kept under lock in the nurses office, and they would re-order the pills when needed. That worked !! I think it was more the nursing uniform that made him think he better take his meds :)
Now, I don't know if you could hire someone to come to Dad's home to do that as a part-time caregiver who is licensed to dispense medicines.